Circumcision is an operation done for removal of the foreskin of the penis in boys.
Why is circumcision done?
In many cultures this is routinely performed for all boys at various ages called religious or cultural circumcision.
Sometimes it has to be done for recurrent infections of the skin in children called Balanoposthitis.
Is it necessary to do circumcision if the foreskin cannot be pulled back?
It is common for the foreskin to not be retractile in boys up to 3 years of age and hence before this age, circumcision is very rarely indicated. This condition is called physiological phimosis and it may persist up to 10 years of age but at an older age some treatment such as gentle retractions in warm water bath and steroid ointments may be recommended by your child’s paediatric surgeon. Sometimes despite best measures this may also require surgery.
How is circumcision done?
Circumcision is done by a paediatric surgeon usually as a day care procedure. This means that the child can be brought to hospital in the morning and get discharged the same day after surgery. Read more about day care procedures here.
The procedure is performed under general anaesthesia as that ensures that the child does not feel any pain and is not aware of the procedure. read more about the safety of general anaesthesia in children here.
The paediatric surgeon cuts the foreskin at the level where the glans penis joins the shaft, called coronal sulcus. The two layers of the skin may be sutured or glued together.
A dressing is usually not required but can be applied if the child or parents wish to have it.
An antibiotic and pain killer are given and the child is discharged home once he has passed urine and is fully awake, usually 4-6 hours after surgery.
What are the complications of circumcision?
Although complications are rare (<5%) they may include persistent bleeding or infection of the wound. Bleeding may occur from the operated wound and it may be controlled by firm pressure and rarely may need be stopped under anaesthesia.
Infection is also rare but can be usually controlled by oral antibiotics and sitz bath.
What care is required after surgery?
No special care is required except keeping the wound clean and not using tight undergarments. After 2-3 days, the child may be given a sit bath once a day. Read more about sitz bath here.
Although no distinct cause has been determined, Parkinson’s disease is due to gradual loss of cells in an area deep within the brain called substantia nigra, which normally produces a chemical called dopamine. Once produced, dopamine travels to other portions of the brain.
One portion called the striatum is the coordination center for various brain circuits. As there is insufficient dopamine in the striatum, the chemical imbalance leads to the symptoms of Parkinson’s disease. Later in the disease, cells in other portion of the brain and nervous system also degenerate.
No one knows why this dopamine producing cells die. Scientists are exploring several theories including chemical reactions within the body, exposure to toxic substances and certain genetic factors. A new gene in certain families suffering from Parkinson’s disease known as “Parkin gene” has been identified to be the positive factor for Parkinson’s disease.
However this has been found to be positive in a small group of patients with young onset of Parkinson’s disease. The research is still going on to find out the real cause for Parkinson’s disease in large patient population
Parkinson’s disease (PD) even to date essentially remains a clinical diagnosis and there are no definitive laboratory tests or brain scans to confirm the diagnosis. Most of these tests are diagnosed to eliminate other diseases that mimic PD.
Patients of PD patients may experience the following symptoms:
Tremor – Slight shaking or tremor in fingers, thumb, hand, chin or lip. Legs shake on sitting down or when relaxing. Tremors is a common and early sign of PD. The typical PD tremors are also called peel rolling tremors, as if one is rolling peels. The tremors are experienced at rest and usually are mild in nature. They disappear on action and activities like drinking and eating.
Micrographia – Sudden change in handwriting which becomes much smaller than the earlier one. The letter sizes become smaller and words tend to be crowded together. Sudden change in handwriting is often a sign of PD. The handwriting diminishes in height from the beginning to the end of the sentence. This is called micrographia.
Rigidity – Patients of PD describe that their body to have become very stiff and the coordinated body movements are lacking making them difficult to carry out their day to day activities like difficulty in arising from chair, turning in bed etc.
Bradykinesia – It is characterized by slowness of movements. The patient has decreased arm swing whilst waking.. It is also manifested in other activities of daily living. The relatives often describe that the patient has slowed down considerably in past few months.
Advanced aging – Young adults rarely experience Parkinson’s disease. It usually demonstrates itself in the middle to late years of life. The risk continues to increase the older one gets. Investigators assume that people with Parkinson’s have neural damage from genetic or ecological factors that get worse as they age. People usually develop the disease around age 60 or older.
Heredity – Having a close relative with Parkinson’s Disease increases the chances that you’ll develop the disease. However, your risks are still small unless you have many relatives in your family with Parkinson’s disease.
Sex – Men are more likely to get Parkinson’s than women. Potential reasons for this may be that males have larger exposure to other risk factors such as toxin exposure or head trauma. It has been hypothesized that oestrogen may have neuro-protective effects OR in the case of hereditary predisposition, a gene predisposing someone to Parkinson’s may be linked to the X chromosome
Selection of medication and their dosage is tailored to each individual patient. In deciding the treatment, the physician considers factors such as severity of symptoms, the patient’s age, and presence of other medical conditions. No two patients will respond identically to any particular drug, so this process involves experimentation with different drugs, persistence and patience. As the disease progresses, drug dosages may have to be altered and a combination of drugs can be given.
A combination of Levodopa and Carbidopa is the mainstay of treatment in Parkinson’s disease. Levodopa is rapidly converted into dopamine, by the enzyme dopa decarboxylase, which is present in the central and peripheral nervous system, however much of the levodopa is metabolized before it reaches the brain.
Carbidopa blocks the peripheral metabolism of levodopa i.e. in the liver, and increases the amount of levodopa that reaches the brain. Levodopa is most effective in treating bradykinesia and rigidity, less effective in reducing tremor, and very less effective in relieving problems with balance.
Side effects include nausea, low blood pressure (hypotension) and abnormal movement’s i.e. dyskinesias.
Slow dosage adjustment and taking medication with food can reduce these effects. Depression, confusion and visual hallucinations are the side effects which may occur with these medications, especially in the elderly.
The key pathology in Parkinson’s Disease (PD) is α-synuclein accumulation. Large α-synuclein aggregates form round lamellate eosinophilic cytoplasmic inclusions, Lewy bodies (LBs) in the neuronal body. α-synuclein is toxic. Its accumulation impairs the functions of the cell. The core pathology of PD affects the dopamine-producing neurons of the substantia Nigra (SN). In advanced PD, loss of pigmented neurons results in gross depigmentation of the SN.
The triad of rigidity, bradykinesia and tremor at rest correlates with degeneration of the dopaminergic nigrostriatal pathway and dopamine depletion in the striatum. α-synuclein deposits and LBs are also present in the cerebral cortex, limbic system and in many extra-nigral neuronal groups. This is the underlying pathology for PD.
Parkinson’s Disease (PD) is just one of several neurologic movement disorders that produce similar symptoms. It is important that the physician you are seeing has experience with all of the different disorders that can masquerade as Parkinson’s disease.
The diagnosis of PD is entirely clinical. It is characterized by tremors, slowness of movements (bradykinesia), stiffness (rigidity), postural imbalance and gait disturbances. In various patients combination of any of the above symptoms can be seen. One of the distinguishing feature of PD from other Parkinson’s like diseases, is its classical response to medical treatment in the early years. According to one estimate, there can be an error of upto 40% in diagnosis when the patient is seen by non-specialist. As there are no radiological (i.e. CT scan, MRI) or blood investigations that can confirm the diagnosis of PD, the onus of diagnosis rests on the physician.
It is very important to make a correct diagnosis. As in some of these diseases, like Progressive supranuclear palsy, Cortico-basal ganglionic degeneration or Multiple system atrophy, people quickly become totally disabled and the surgical interventions in such cases can be disastrous to say the least.
While there’s no food or combination of foods proven to help in Parkinson’s Disease (PD), some foods may help ease some of the symptoms. For example, eating foods high in fiber and drinking an adequate amount of fluids can help prevent constipation that is common in PD. A balanced diet also provides nutrients, such as omega-3 fatty acids, that may be beneficial for people with PD.
For appointments we suggest you to know the doctor’s weekly schedule so that you can make an appointment.
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